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Drugs used off label may have unrecognized safety and efficacy problems.
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Roflumilast represents the first in a new class of agents to treat COPD and, if approved, would be the first oral anti-inflammatory maintenance treatment for the disease.
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Roflumilast is a new PDE4 inhibitor being developed specifically to target the chronic inflammation which is COPD-related.
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But getting patients to get up off the couch and exercise regularly is a tough sell when compared to getting an angioplasty, which involves opening arteries with a tiny balloon and then inserting a mesh tube called a stent.
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